Ontology highlight
ABSTRACT:
SUBMITTER: Javanmard Khameneh H
PROVIDER: S-EPMC6644529 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Javanmard Khameneh Hanif H Leong Keith Weng Kit KWK Mencarelli Andrea A Vacca Maurizio M Mambwe Bezaleel B Neo Kurt K Tay Alice A Zolezzi Francesca F Lee Bernett B Mortellaro Alessandra A
Frontiers in immunology 20190715
The inflammasome is a multi-protein complex that mediates proteolytic cleavage and release of the pro-inflammatory cytokines IL-1β and IL-18, and pyroptosis-a form of cell death induced by various pathogenic bacteria. Apoptosis-associated speck-like protein containing a CARD (ASC) has a pivotal role in inflammasome assembly and activation. While ASC function has been primarily implicated in innate immune cells, its contribution to lymphocyte biology is unclear. Here we report that ASC is constit ...[more]