Ontology highlight
ABSTRACT:
SUBMITTER: Sen S
PROVIDER: S-EPMC6644700 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Sen Sudeshna S Mondal Santanu S Zheng Li L Salinger Ari J AJ Fast Walter W Weerapana Eranthie E Thompson Paul R PR
ACS chemical biology 20190405 4
Nicotinamide N-methyltransferase (NNMT) catalyzes the S-adenosyl-l-methionine-dependent methylation of nicotinamide to form N-methylnicotinamide. This enzyme detoxifies xenobiotics and regulates NAD<sup>+</sup> biosynthesis. Additionally, NNMT is overexpressed in various cancers. Herein, we describe the first NNMT-targeted suicide substrates. These compounds, which include 4-chloropyridine and 4-chloronicotinamide, exploit the broad substrate scope of NNMT; methylation of the pyridine nitrogen e ...[more]