Colorimetric Calcium Probe with Comparison to an Ion-Selective Optode.
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ABSTRACT: Design strategies for small molecular probes lay the foundation of numerous synthetic chemosensors. A water-soluble colorimetric calcium molecular probe inspired by the ionophore-based ion-selective optode is presented here with a tunable detection range (around micromolar at pH 7). The binding of Ca2+ resulted in the deprotonation of the probe and thus a significant spectral change, mimicking the ion-exchange process in ion-selective optodes. The 1:1 exchange between Ca2+ and H+ was confirmed with Job's plot. Computational studies revealed possible monomer and dimer forms of the probe-Ca2+ complexes.
SUBMITTER: Zhu C
PROVIDER: S-EPMC6644788 | biostudies-literature |
REPOSITORIES: biostudies-literature
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