A Biocompatible Colorimetric Triphenylamine- Dicyanovinyl Conjugated Fluorescent Probe for Selective and Sensitive Detection of Cyanide Ion in Aqueous Media and Living Cells.

ABSTRACT: A colorimetric and turn-on fluorescent probe 1 bearing triphenylamine-thiophene and dicyanovinyl groups has been synthesized and used to detect cyanide anion via a nucleophilic addition reaction. Probe 1 exhibited prominent selectivity and sensitivity towards CN^- in aqueous media, even in the presence of other anions such as S^2-, HS^-, SO?^2-, S?O?^2-, S?O?^2-, I^-, Br^-, Cl^-, F^-, NO?^-, N?^-, SO?^2-, SCN^-, HCO?^-, CO?^2- and AcO^-. Moreover, a low detection limit (LOD, 51 nM) was observed. In addition, good cell membrane permeability and low cytotoxicity to HeLa cells were also observed, suggesting its promising potential in bio-imaging.

SUBMITTER: Zheng ZH 

PROVIDER: S-EPMC5336021 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature