Dataset Information

Cubical-Shaped Rods of Pectin-Hydroxyapatite Composite for Adsorption Studies of Fluoride by Statistical Method and Adsorption Experiments.

ABSTRACT: This research details the synthesis and application of a novel pectin-hydroxyapatite (PHAp) composite for fluoride (F-) adsorption from aqueous solutions. To determine the efficiency of the adsorption process parameters, i.e., adsorbent dose (0.1-0.4 g), initial fluoride concentration (10-30 mg/L), and temperature (298-313 K), the Box-Behnken design with three levels and three factors have been utilized. The quadratic model was established on 27 batch runs by regression analysis of the experimental data of these runs. The efficacy of adsorption was observed using the Langmuir and Freundlich models. The adsorption rate was found at 3.17 mg g-1min-1, and adsorption kinetics followed pseudo-second order (PSO) for PHAp. The significant novelty of this work is the synthesis of unique cubical-shaped rods biopolymer composite from hydroxyapatite. Additionally, this composite showed high adsorption capacity for F- compared to other hydroxyapatite adsorbents, and the improved adsorption capacity is attributed to its unique shape which provides a larger surface area. It can be reused for up to six cycles, which makes this method environment-friendly. The economic viability of the synthesized PHAp composite, in comparison to other adsorbents, is evident from the cost-benefit analysis.

SUBMITTER: Raghav S

PROVIDER: S-EPMC6644855 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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Cubical-Shaped Rods of Pectin-Hydroxyapatite Composite for Adsorption Studies of Fluoride by Statistical Method and Adsorption Experiments.

Raghav Sapna S Sapna Kumar Dinesh D

ACS omega 20180821 8

This research details the synthesis and application of a novel pectin-hydroxyapatite (PHAp) composite for fluoride (F<sup>-</sup>) adsorption from aqueous solutions. To determine the efficiency of the adsorption process parameters, i.e., adsorbent dose (0.1-0.4 g), initial fluoride concentration (10-30 mg/L), and temperature (298-313 K), the Box-Behnken design with three levels and three factors have been utilized. The quadratic model was established on 27 batch runs by regression analysis of th ...[more]

PMID: 31459097

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Project description:UnlabelledBenzoxaboroles are a family of molecules that are finding an increasing number of applications in the biomedical field, particularly as a "privileged scaffold" for the design of new drugs. Here, for the first time, we determine the interaction of these molecules with hydroxyapatites, in view of establishing (i) how benzoxaborole drugs may adsorb onto biological apatites, as this could impact on their bioavailability, and (ii) how apatite-based materials can be used for their formulation. Studies on the adsorption of the benzoxaborole motif (C7H7BO2, referred to as BBzx) on two different apatite phases were thus performed, using a ceramic hydroxyapatite (HAceram) and a nanocrystalline hydroxyapatite (HAnano), the latter having a structure and composition more similar to the one found in bone mineral. In both cases, the grafting kinetics and mechanism were studied, and demonstration of the surface attachment of the benzoxaborole under the form of a tetrahedral benzoxaborolate anion was established using (11)B solid state NMR (including (11)B-(31)P correlation experiments). Irrespective of the apatite used, the grafting density of the benzoxaborolates was found to be low, and more generally, these anions demonstrated a poor affinity for apatite surfaces, notably in comparison with other anions commonly found in biological media, such as carboxylates and (organo)phosphates. The study was then extended to the adsorption of a molecule with antimicrobial and antifungal properties (3-piperazine-bis(benzoxaborole)), showing, on a more general perspective, how hydroxyapatites can be used for the development of novel formulations of benzoxaborole drugs.Statement of significanceBenzoxaboroles are an emerging family of molecules which have attracted much attention in the biomedical field, notably for the design of new drugs. However, the way in which these molecules, once introduced in the body, may interact with bone mineral is still unknown, and the possibility of associating benzoxaboroles to calcium phosphates for drug-formulation purposes has not been looked into. Here, we describe the first study of the adsorption of benzoxaboroles on hydroxyapatite, which is the main mineral phase present in bone. We describe the mode of grafting of benzoxaboroles on this material, and show that they only weakly bind to its surface, especially in comparison to other ionic species commonly found in physiological media, such as phosphates and carboxylates. This demonstrates that administered benzoxaborole drugs are unlikely to remain adsorbed on hydroxyapatite surfaces for long periods of time, which means that their biodistribution will not be affected by such phenomena. Moreover, this work shows that the formulation of benzoxaborole drugs by association to calcium phosphates like hydroxyapatite will lead to a rapid release of the molecules.

Project description:BackgroundThe incorporation of prior biological knowledge in the analysis of microarray data has become important in the reconstruction of transcription regulatory networks in a cell. Most of the current research has been focused on the integration of multiple sets of microarray data as well as curated databases for a genome scale reconstruction. However, individual researchers are more interested in the extraction of most useful information from the data of their hypothesis-driven microarray experiments. How to compile the prior biological knowledge from literature to facilitate new hypothesis generation from a microarray experiment is the focus of this work. We propose a novel method based on the statistical analysis of reported gene interactions in PubMed literature.ResultsUsing Gene Ontology (GO) Molecular Function annotation for reported gene regulatory interactions in PubMed literature, a statistical analysis method was proposed for the derivation of a likelihood of interaction (LOI) score for a pair of genes. The LOI-score and the Pearson correlation coefficient of gene profiles were utilized to check if a pair of query genes would be in the above specified interaction. The method was validated in the analysis of two gene sets formed from the yeast Saccharomyces cerevisiae cell cycle microarray data. It was found that high percentage of identified interactions shares GO Biological Process annotations (39.5% for a 102 interaction enriched gene set and 23.0% for a larger 999 cyclically expressed gene set).ConclusionThis method can uncover novel biologically relevant gene interactions. With stringent confidence levels, small interaction networks can be identified for further establishment of a hypothesis testable by biological experiment. This procedure is computationally inexpensive and can be used as a preprocessing procedure for screening potential biologically relevant gene pairs subject to the analysis with sophisticated statistical methods.

Dataset Information

Cubical-Shaped Rods of Pectin-Hydroxyapatite Composite for Adsorption Studies of Fluoride by Statistical Method and Adsorption Experiments.

Publications

Cubical-Shaped Rods of Pectin-Hydroxyapatite Composite for Adsorption Studies of Fluoride by Statistical Method and Adsorption Experiments.

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