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Faster and Greener Chemical Reaction Workup Using Silicone Elastomer-Coated Glass Powders.


ABSTRACT: We have developed a substantially faster and greener technique for routine chemical reaction workups. We use silicone elastomer-coated glass powder ("FastWoRX") as an absorbent to extract organic products from a quenched aqueous reaction mixture. After filtration, FastWoRX powder loaded with organic products can serve as a convenient input for flash chromatographic separations. With this technique, tedious and solvent-consuming liquid-liquid extractions are replaced by a simple filtration. Use of FastWoRX reduces solvent use and the E-factor by up to an order of magnitude compared to traditional liquid-liquid extraction-based workup.

SUBMITTER: Shi Z 

PROVIDER: S-EPMC6644892 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature

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Faster and Greener Chemical Reaction Workup Using Silicone Elastomer-Coated Glass Powders.

Shi Zhenyu Z   Hammond Gerald B GB   Xu Bo B  

ACS omega 20180621 6


We have developed a substantially faster and greener technique for routine chemical reaction workups. We use silicone elastomer-coated glass powder ("FastWoRX") as an absorbent to extract organic products from a quenched aqueous reaction mixture. After filtration, FastWoRX powder loaded with organic products can serve as a convenient input for flash chromatographic separations. With this technique, tedious and solvent-consuming liquid-liquid extractions are replaced by a simple filtration. Use o  ...[more]

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