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Propagating Precipitation Waves in Disordered Media.

ABSTRACT: The study presented in this paper investigates form changes of propagating waves generated through precipitation reactions in a gel matrix that possesses an inhomogeneous microstructure. The waves demonstrate form changes from a single ring-like pattern to multiple target-like waves. Subsequently, the waves take up a spiral form and ultimately manifest themselves in the form of a turbulence pattern that intensifies with increasing fluctuations within the gel structure. An investigation into the dynamics of the precipitation waves reveals the existence of an anomalous diffusion. The effective diffusion coefficients are found to increase linearly with the quenching temperature. Further, it is revealed through the analysis of the anomalous diffusion dynamics that precipitation patterns could be adequately controlled by adjusting the permeability fluctuations within the gel structure. The findings of this study lead to a greater understanding of the spontaneous creation of precipitation patterns by a system driven by disorder.

SUBMITTER: Ban T

PROVIDER: S-EPMC6645417 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature

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Propagating Precipitation Waves in Disordered Media.

Ban Takahiko T Kaji Masaru M Nagatsu Yuichiro Y Tokuyama Hideaki H

ACS omega 20171116 11

The study presented in this paper investigates form changes of propagating waves generated through precipitation reactions in a gel matrix that possesses an inhomogeneous microstructure. The waves demonstrate form changes from a single ring-like pattern to multiple target-like waves. Subsequently, the waves take up a spiral form and ultimately manifest themselves in the form of a turbulence pattern that intensifies with increasing fluctuations within the gel structure. An investigation into the ...[more]

PMID: 31457353

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Project description:The ability of cells to coordinately migrate in groups is crucial to enable them to travel long distances during embryonic development, wound healing and tumorigenesis, but the fundamental mechanisms underlying intercellular coordination during collective cell migration remain elusive despite considerable research efforts. A novel analytical framework is introduced here to explicitly detect and quantify cell clusters that move coordinately in a monolayer. The analysis combines and associates vast amount of spatiotemporal data across multiple experiments into transparent quantitative measures to report the emergence of new modes of organized behavior during collective migration of tumor and epithelial cells in wound healing assays. First, we discovered the emergence of a wave of coordinated migration propagating backward from the wound front, which reflects formation of clusters of coordinately migrating cells that are generated further away from the wound edge and disintegrate close to the advancing front. This wave emerges in both normal and tumor cells, and is amplified by Met activation with hepatocyte growth factor/scatter factor. Second, Met activation was found to induce coinciding waves of cellular acceleration and stretching, which in turn trigger the emergence of a backward propagating wave of directional migration with about an hour phase lag. Assessments of the relations between the waves revealed that amplified coordinated migration is associated with the emergence of directional migration. Taken together, our data and simplified modeling-based assessments suggest that increased velocity leads to enhanced coordination: higher motility arises due to acceleration and stretching that seems to increase directionality by temporarily diminishing the velocity components orthogonal to the direction defined by the monolayer geometry. Spatial and temporal accumulation of directionality thus defines coordination. The findings offer new insight and suggest a basic cellular mechanism for long-term cell guidance and intercellular communication during collective cell migration.

Dataset Information

Propagating Precipitation Waves in Disordered Media.

Publications

Propagating Precipitation Waves in Disordered Media.

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