Ontology highlight
ABSTRACT:
SUBMITTER: Visnes T
PROVIDER: S-EPMC6645780 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20181101 6416
The onset of inflammation is associated with reactive oxygen species and oxidative damage to macromolecules like 7,8-dihydro-8-oxoguanine (8-oxoG) in DNA. Because 8-oxoguanine DNA glycosylase 1 (OGG1) binds 8-oxoG and because <i>Ogg1</i>-deficient mice are resistant to acute and systemic inflammation, we hypothesized that OGG1 inhibition may represent a strategy for the prevention and treatment of inflammation. We developed TH5487, a selective active-site inhibitor of OGG1, which hampers OGG1 bi ...[more]