Ontology highlight
ABSTRACT:
SUBMITTER: Baquero JM
PROVIDER: S-EPMC7876102 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Baquero Juan Miguel JM Benítez-Buelga Carlos C Rajagopal Varshni V Zhenjun Zhao Z Torres-Ruiz Raúl R Müller Sarah S Hanna Bishoy M F BMF Loseva Olga O Wallner Olov O Michel Maurice M Rodríguez-Perales Sandra S Gad Helge H Visnes Torkild T Helleday Thomas T Benítez Javier J Osorio Ana A
Scientific reports 20210210 1
The most common oxidative DNA lesion is 8-oxoguanine which is mainly recognized and excised by the 8-oxoG DNA glycosylase 1 (OGG1), initiating the base excision repair (BER) pathway. Telomeres are particularly sensitive to oxidative stress (OS) which disrupts telomere homeostasis triggering genome instability. In the present study, we have investigated the effects of inactivating BER in OS conditions, by using a specific inhibitor of OGG1 (TH5487). We have found that in OS conditions, TH5487 blo ...[more]