Unknown

Dataset Information

0

The roles of p38 MAPK???COX2 and NF-?B???COX2 signal pathways in age-related testosterone reduction.

ABSTRACT: In our study, we explored changes in the redox status and inflammatory response in the testes of the SAMP8 model of varying ages (2, 4, 8, 10 months old) compared with control mice SAMR1 by the methods of immunohistochemical staining, Western blotting, RT-PCR and Luminex multi-analyte cytokine profiling. We found that as ROS and inflammation levels increased during aging, steroidogenic enzymes (StAR and P450scc) reduced and led to the decline of testosterone production eventually. The pathways of P38 MAPK???COX2 and NF-?B???COX2 were detected by using specific inhibitors of SB203580 and Bay 11-7082 in isolated Leydig cells. These results indicated that activation of both p38 MAPK???COX2 and NF-?B???COX2 signaling pathways are functionally linked to the oxidative stress response and chronic inflammation during aging, and mediate their inhibitory effects on testosterone production.

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC6646396 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

The roles of p38 MAPK → COX2 and NF-κB → COX2 signal pathways in age-related testosterone reduction.

Zhao Yu Y   Liu Xuehui X   Qu Yine Y   Wang Lixuan L   Geng Dan D   Chen Wei W   Li Li L   Tian Yangyang Y   Chang Shiyang S   Zhao Chunfang C   Zhao Xiujun X   Lv Pin P  

Scientific reports 20190722 1

In our study, we explored changes in the redox status and inflammatory response in the testes of the SAMP8 model of varying ages (2, 4, 8, 10 months old) compared with control mice SAMR1 by the methods of immunohistochemical staining, Western blotting, RT-PCR and Luminex multi-analyte cytokine profiling. We found that as ROS and inflammation levels increased during aging, steroidogenic enzymes (StAR and P450scc) reduced and led to the decline of testosterone production eventually. The pathways o  ...[more]

Similar Datasets

Unknown Oxymatrine Inhibits Influenza A Virus Replication and Inflammation via TLR4, p38 MAPK and NF-?B Pathways.
| S-EPMC5979549 | biostudies-literature
Unknown Salvianolic Acid A Exhibits Anti-Inflammatory and Antiarthritic Effects via Inhibiting NF-?B and p38/MAPK Pathways.
| S-EPMC7217308 | biostudies-literature
Unknown Rapamycin regulates macrophage activation by inhibiting NLRP3 inflammasome-p38 MAPK-NF?B pathways in autophagy- and p62-dependent manners.
| S-EPMC5522223 | biostudies-literature
Unknown Hemokinin-1 gene expression is upregulated in microglia activated by lipopolysaccharide through NF-κB and p38 MAPK signaling pathways.
| S-EPMC3288086 | biostudies-literature
Unknown Vitamin K2 Induces Mitochondria-Related Apoptosis in Human Bladder Cancer Cells via ROS and JNK/p38 MAPK Signal Pathways.
| S-EPMC5003392 | biostudies-literature
Unknown Tripterygium wilfordii Glycosides Upregulate the New Anti-Inflammatory Cytokine IL-37 through ERK1/2 and p38 MAPK Signal Pathways.
| S-EPMC5748296 | biostudies-literature
Unknown Sulforaphane Inhibits MGO-AGE-Mediated Neuroinflammation by Suppressing NF-?B, MAPK, and AGE-RAGE Signaling Pathways in Microglial Cells.
| S-EPMC7554773 | biostudies-literature
Unknown Death receptor 6 (DR6) is required for mouse B16 tumor angiogenesis via the NF-?B, P38 MAPK and STAT3 pathways.
| S-EPMC4815052 | biostudies-literature
Unknown A novel synthetic compound MCAP suppresses LPS-induced murine microglial activation in vitro via inhibiting NF-kB and p38 MAPK pathways.
| S-EPMC4775849 | biostudies-literature
Unknown The UII/UT system mediates upregulation of proinflammatory cytokines through p38 MAPK and NF-?B pathways in LPS-stimulated Kupffer cells.
| S-EPMC4372515 | biostudies-literature