Ontology highlight
ABSTRACT:
SUBMITTER: Su G
PROVIDER: S-EPMC6649716 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Su Guangsong G Guo Dianhao D Chen Jun J Liu Man M Zheng Jian J Wang Wenbin W Zhao Xueyuan X Yin Qingqing Q Zhang Lei L Zhao Zhongfang Z Shi Jiandang J Lu Wange W
Nucleic acids research 20190701 13
Retinoic acid (RA) induces rapid differentiation of embryonic stem cells (ESCs), partly by activating expression of the transcription factor Hoxa1, which regulates downstream target genes that promote ESCs differentiation. However, mechanisms of RA-induced Hoxa1 expression and ESCs early differentiation remain largely unknown. Here, we identify a distal enhancer interacting with the Hoxa1 locus through a long-range chromatin loop. Enhancer deletion significantly inhibited expression of RA-induce ...[more]