Ontology highlight
ABSTRACT:
SUBMITTER: Moon BS
PROVIDER: S-EPMC9925822 | biostudies-literature | 2023 Feb
REPOSITORIES: biostudies-literature
Cell death discovery 20230213 1
Nuclear architecture underlies the transcriptional programs within the cell to establish cell identity. As previously demonstrated, long-range chromatin interactions of the Oct4 distal enhancer (DE) are correlated with active transcription in naïve state embryonic stem cells. Here, we identify and characterize extreme long-range interactions of the Oct4 DE through a novel CRISPR labeling technique we developed and chromosome conformation capture to identify lethal giant larvae 2 (Llgl2) and grow ...[more]