Circulating PD-1⁺CXCR5^-CD4⁺ T cells underlying the immunological mechanisms of IgG4-related disease.

ABSTRACT:

Objective

The aim was to study the pathological role of lymphocytes with a peripheral T helper-cell-like phenotype (PD-1⁺CXCR5^-CD4⁺) in IgG4-related disease (IgG4-RD).

Methods

PD-1⁺CXCR5^-CD4⁺ T cells in the blood of patients with IgG4-RD (n = 53), patients with SS (n = 16) and healthy volunteers (n = 34) as controls were analysed by flow cytometry. Correlations between results obtained by flow cytometry and clinical parameters relevant to IgG4-RD were also analysed.

Results

The percentage and absolute number of PD-1⁺CXCR5^- cells within total CD4⁺ T cells in IgG4-RD patients were significantly increased compared with those in healthy volunteers. Furth

SUBMITTER: Kamekura R 

PROVIDER: S-EPMC6649940 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature