Ontology highlight
ABSTRACT:
SUBMITTER: Marshall CH
PROVIDER: S-EPMC6650168 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Marshall Catherine H CH Imada Eddie L EL Tang Zhuojun Z Marchionni Luigi L Antonarakis Emmanuel S ES
Oncoscience 20190510 5-6
Inactivating <i>CDK12</i> alterations have been reported in ovarian and prostate cancers and may have therapeutic implications; however, the prevalence of these mutations across other cancer types is unknown. We searched the cBioPortal and GENIE Project (public release v4.1) databases for cancer types with > 200 sequenced cases, that included patients with metastatic disease, and in which the occurrence of at least monoallelic <i>CDK12</i> alterations was > 1%. The prevalence of at least monoall ...[more]