Actionable molecular biomarkers in primary brain tumors.
Ontology highlight
ABSTRACT:
SUBMITTER: Staedtke V
PROVIDER: S-EPMC5461965 | biostudies-other | 2016 Jul
REPOSITORIES: biostudies-other
Publications
Actionable molecular biomarkers in primary brain tumors.
Staedtke Verena V Dzaye Omar Dildar a O Holdhoff Matthias M
Trends in cancer 20160701 7
Recent genome-wide studies of malignancies of the central nervous system (CNS) have revolutionized our understanding of the biology of these tumors. This newly gained knowledge provides a wealth of opportunity for biomarker driven clinical research. To date, however, only few of the available molecular markers truly influence clinical decision-making and treatment. The most widely validated markers in neuro-oncology presently are: 1) <i>MGMT promoter methylation</i> as a prognostic and predictiv ...[more]
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