The Transcriptional Regulator Id2 Is Critical for Adipose-Resident Regulatory T Cell Differentiation, Survival, and Function.
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ABSTRACT:
SUBMITTER: Frias AB
PROVIDER: S-EPMC6650328 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
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The Transcriptional Regulator Id2 Is Critical for Adipose-Resident Regulatory T Cell Differentiation, Survival, and Function.
Frias Adolfo B AB Hyzny Eric J EJ Buechel Heather M HM Beppu Lisa Y LY Xie Bingxian B Jurczak Michael J MJ D'Cruz Louise M LM
Journal of immunology (Baltimore, Md. : 1950) 20190614 3
Adipose regulatory T cells (aTregs) have emerged as critical cells for the control of local and systemic inflammation. In this study, we show a distinctive role for the transcriptional regulator Id2 in the differentiation, survival, and function of aTregs in mice. Id2 was highly expressed in aTregs compared with high Id3 expression in lymphoid regulatory T cells (Tregs). Treg-specific deletion of Id2 resulted in a substantial decrease in aTregs, whereas Tregs in the spleen and lymph nodes were u ...[more]
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