Ontology highlight
ABSTRACT:
SUBMITTER: Emery B
PROVIDER: S-EPMC2757090 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Emery Ben B Agalliu Dritan D Cahoy John D JD Watkins Trent A TA Dugas Jason C JC Mulinyawe Sara B SB Ibrahim Adilijan A Ligon Keith L KL Rowitch David H DH Barres Ben A BA
Cell 20090701 1
The transcriptional control of CNS myelin gene expression is poorly understood. Here we identify gene model 98, which we have named myelin gene regulatory factor (MRF), as a transcriptional regulator required for CNS myelination. Within the CNS, MRF is specifically expressed by postmitotic oligodendrocytes. MRF is a nuclear protein containing an evolutionarily conserved DNA binding domain homologous to a yeast transcription factor. Knockdown of MRF in oligodendrocytes by RNA interference prevent ...[more]