Ontology highlight
ABSTRACT:
SUBMITTER: Robert-Paganin J
PROVIDER: S-EPMC6650474 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Robert-Paganin Julien J Robblee James P JP Auguin Daniel D Blake Thomas C A TCA Bookwalter Carol S CS Krementsova Elena B EB Moussaoui Dihia D Previs Michael J MJ Jousset Guillaume G Baum Jake J Trybus Kathleen M KM Houdusse Anne A
Nature communications 20190723 1
Plasmodium parasites are obligate intracellular protozoa and causative agents of malaria, responsible for half a million deaths each year. The lifecycle progression of the parasite is reliant on cell motility, a process driven by myosin A, an unconventional single-headed class XIV molecular motor. Here we demonstrate that myosin A from Plasmodium falciparum (PfMyoA) is critical for red blood cell invasion. Further, using a combination of X-ray crystallography, kinetics, and in vitro motility ass ...[more]