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Isoforms of Base Excision Repair Enzymes Produced by Alternative Splicing.

ABSTRACT: Transcripts of many enzymes involved in base excision repair (BER) undergo extensive alternative splicing, but functions of the corresponding alternative splice variants remain largely unexplored. In this review, we cover the studies describing the common alternatively spliced isoforms and disease-associated variants of DNA glycosylases, AP-endonuclease 1, and DNA polymerase beta. We also discuss the roles of alternative splicing in the regulation of their expression, catalytic activities, and intracellular transport.

SUBMITTER: Boldinova EO

PROVIDER: S-EPMC6651865 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Isoforms of Base Excision Repair Enzymes Produced by Alternative Splicing.

Boldinova Elizaveta O EO Khairullin Rafil F RF Makarova Alena V AV Zharkov Dmitry O DO

International journal of molecular sciences 20190703 13

Transcripts of many enzymes involved in base excision repair (BER) undergo extensive alternative splicing, but functions of the corresponding alternative splice variants remain largely unexplored. In this review, we cover the studies describing the common alternatively spliced isoforms and disease-associated variants of DNA glycosylases, AP-endonuclease 1, and DNA polymerase beta. We also discuss the roles of alternative splicing in the regulation of their expression, catalytic activities, and i ...[more]

PMID: 31277343

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