Ontology highlight
ABSTRACT:
SUBMITTER: Fernandez-Santiago R
PROVIDER: S-EPMC6651999 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Fernández-Santiago Rubén R Merkel Angelika A Castellano Giancarlo G Heath Simon S Raya Ángel Á Tolosa Eduard E Martí María-José MJ Consiglio Antonella A Ezquerra Mario M
Clinical epigenetics 20190723 1
<h4>Background</h4>Parkinson's disease (PD) is characterized by the loss of midbrain dopaminergic neurons (DAn). Previously, we described the presence of DNA hyper- and hypo-methylation alterations in induced pluripotent stem cells (iPSC)-derived DAn from PD patients using the Illumina 450K array which prominently covers gene regulatory regions.<h4>Methods</h4>To expand and contextualize previous findings, we performed the first whole-genome DNA bisulfite sequencing (WGBS) using iPSC-derived DAn ...[more]