Ontology highlight
ABSTRACT:
SUBMITTER: Song B
PROVIDER: S-EPMC6994130 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Song Bin B Cha Young Y Ko Sanghyeok S Jeon Jeha J Lee Nayeon N Seo Hyemyung H Park Kyung-Joon KJ Lee In-Hee IH Lopes Claudia C Feitosa Melissa M Luna María José MJ Jung Jin Hyuk JH Kim Jisun J Hwang Dabin D Cohen Bruce M BM Teicher Martin H MH Leblanc Pierre P Carter Bob S BS Kordower Jeffrey H JH Bolshakov Vadim Y VY Kong Sek Won SW Schweitzer Jeffrey S JS Kim Kwang-Soo KS
The Journal of clinical investigation 20200201 2
Parkinson's disease (PD) is a neurodegenerative disorder associated with loss of striatal dopamine, secondary to degeneration of midbrain dopamine (mDA) neurons in the substantia nigra, rendering cell transplantation a promising therapeutic strategy. To establish human induced pluripotent stem cell-based (hiPSC-based) autologous cell therapy, we report a platform of core techniques for the production of mDA progenitors as a safe and effective therapeutic product. First, by combining metabolism-r ...[more]