Ontology highlight
ABSTRACT:
SUBMITTER: Bugler J
PROVIDER: S-EPMC6652210 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Bugler Jane J Kinstrie Ross R Scott Mary T MT Vetrie David D
Frontiers in cell and developmental biology 20190717
Chronic myeloid leukemia (CML) is a hematopoietic stem cell disorder characterized by BCR-ABL1, an oncogenic fusion gene arising from the Philadelphia chromosome. The development of tyrosine kinase inhibitors (TKIs) to overcome the constitutive tyrosine kinase activity of the BCR-ABL protein has dramatically improved disease management and patient outcomes over the past 20 years. However, the majority of patients are not cured and developing novel therapeutic strategies that target epigenetic pr ...[more]