Ontology highlight
ABSTRACT:
SUBMITTER: Hanson WG
PROVIDER: S-EPMC6652770 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Infection and immunity 20190723 8
Live-attenuated <i>Listeria monocytogenes</i> has shown encouraging potential as an immunotherapy platform in preclinical and clinical settings. However, additional safety measures will enable application across malignant and infectious diseases. Here, we describe a new vaccine platform, termed Lm-RIID (<i>L. monocytogenes</i> recombinase-induced intracellular death), that induces the deletion of genes required for bacterial viability yet maintains potent T cell responses to encoded antigens. Lm ...[more]