Dataset Information

Associations of HbA1c with the timing of C-peptide responses during the oral glucose tolerance test at the diagnosis of type 1 diabetes.

ABSTRACT:

Background

In new onset type 1 diabetes (T1D), overall C-peptide measures such as area under the curve (AUC) C-peptide and peak C-peptide are useful for estimating the extent of β-cell dysfunction, and for assessing responses to intervention therapy. However, measures of the timing of C-peptide responsiveness could have additional value.

Objectives

We assessed the contribution of the timing of C-peptide responsiveness during oral glucose tolerance tests (OGTTs) to hemoglobin A1c (HbA1c) variation at T1D diagnosis.

Methods

We analyzed data from 85 individuals <18 years with OGTTs and HbA1c measurements at diagnosis. Overall [AUC and peak C-peptide] and timing measures [30-0 minute C-peptide (early); 60 to 120 minute C-peptide sum-30 minutes (late); 120/30 C-peptide; time to peak C-peptide] were utilized.

Results

At diagnosis, the mean (±SD) age was 11.2 ± 3.3 years, body mass index (BMI)-z was 0.4 ± 1.1, 51.0% were male. The average HbA1c was 43.54 ± 8.46 mmol/mol (6.1 ± 0.8%). HbA1c correlated inversely with the AUC C-peptide (P < 0.001), peak C-peptide (P < 0.001), early and late C-peptide responses (P < 0.001 each), and 120/30 C-peptide (P < 0.001). Those with a peak C-peptide occurring at ≤60 minutes had higher HbA1c values than those with peaks later (P = 0.003). HbA1c variance was better explained with timing measures added to regression models (R² = 11.6% with AUC C-peptide alone; R² = 20.0% with 120/30 C-peptide added; R² = 13.7% with peak C-peptide alone, R² = 20.4% with timing of the peak added). Similar associations were seen between the 2-hour glucose and the C-peptide measures.

Conclusions

These findings show that the addition of timing measures of C-peptide responsiveness better explains HbA1c variation at diagnosis than standard measures alone.

SUBMITTER: Ismail HM

PROVIDER: S-EPMC6655420 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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Publications

Associations of HbA1c with the timing of C-peptide responses during the oral glucose tolerance test at the diagnosis of type 1 diabetes.

Ismail Heba M HM Evans-Molina Carmella C DiMeglio Linda A LA Becker Dorothy J DJ Libman Ingrid I Sims Emily K EK Boulware David D Herold Kevan C KC Rafkin Lisa L Skyler Jay J Cleves Mario A MA Palmer Jerry J Sosenko Jay M JM

Pediatric diabetes 20190415 4

<h4>Background</h4>In new onset type 1 diabetes (T1D), overall C-peptide measures such as area under the curve (AUC) C-peptide and peak C-peptide are useful for estimating the extent of β-cell dysfunction, and for assessing responses to intervention therapy. However, measures of the timing of C-peptide responsiveness could have additional value.<h4>Objectives</h4>We assessed the contribution of the timing of C-peptide responsiveness during oral glucose tolerance tests (OGTTs) to hemoglobin A1c ( ...[more]

PMID: 30891858

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Dataset Information

Associations of HbA1c with the timing of C-peptide responses during the oral glucose tolerance test at the diagnosis of type 1 diabetes.

Background

Objectives

Methods

Results

Conclusions

Publications

Associations of HbA1c with the timing of C-peptide responses during the oral glucose tolerance test at the diagnosis of type 1 diabetes.

Similar Datasets

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