WDFY4 is required for cross-presentation in response to viral and tumor antigens.
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ABSTRACT:
SUBMITTER: Theisen DJ
PROVIDER: S-EPMC6655551 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
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WDFY4 is required for cross-presentation in response to viral and tumor antigens.
Theisen Derek J DJ Davidson Jesse T JT Briseño Carlos G CG Gargaro Marco M Lauron Elvin J EJ Wang Qiuling Q Desai Pritesh P Durai Vivek V Bagadia Prachi P Brickner Joshua R JR Beatty Wandy L WL Virgin Herbert W HW Gillanders William E WE Mosammaparast Nima N Diamond Michael S MS Sibley L David LD Yokoyama Wayne W Schreiber Robert D RD Schreiber Robert D RD Murphy Theresa L TL Murphy Kenneth M KM
Science (New York, N.Y.) 20181101 6415
During the process of cross-presentation, viral or tumor-derived antigens are presented to CD8<sup>+</sup> T cells by <i>Batf3-</i>dependent CD8α<sup>+</sup>/XCR1<sup>+</sup> classical dendritic cells (cDC1s). We designed a functional CRISPR screen for previously unknown regulators of cross-presentation, and identified the BEACH domain-containing protein WDFY4 as essential for cross-presentation of cell-associated antigens by cDC1s in mice. However, WDFY4 was not required for major histocompatib ...[more]
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