Ontology highlight
ABSTRACT:
SUBMITTER: Parker BL
PROVIDER: S-EPMC6656374 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Parker Benjamin L BL Calkin Anna C AC Seldin Marcus M MM Keating Michael F MF Tarling Elizabeth J EJ Yang Pengyi P Moody Sarah C SC Liu Yingying Y Zerenturk Eser J EJ Needham Elise J EJ Miller Matthew L ML Clifford Bethan L BL Morand Pauline P Watt Matthew J MJ Meex Ruth C R RCR Peng Kang-Yu KY Lee Richard R Jayawardana Kaushala K Pan Calvin C Mellett Natalie A NA Weir Jacquelyn M JM Lazarus Ross R Lusis Aldons J AJ Meikle Peter J PJ James David E DE de Aguiar Vallim Thomas Q TQ Drew Brian G BG
Nature 20190227 7747
Dysregulation of lipid homeostasis is a precipitating event in the pathogenesis and progression of hepatosteatosis and metabolic syndrome. These conditions are highly prevalent in developed societies and currently have limited options for diagnostic and therapeutic intervention. Here, using a proteomic and lipidomic-wide systems genetic approach, we interrogated lipid regulatory networks in 107 genetically distinct mouse strains to reveal key insights into the control and network structure of ma ...[more]