Dataset Information

Neonatal Adipocytokines and Longitudinal Patterns of Childhood Growth.

ABSTRACT:

Objective

Adipocytokines are markers of fetal metabolism, but their association with childhood growth is unclear. This study examined associations of neonatal adipocytokines with longitudinal childhood adiposity measures in a prospective cohort of pregnant women and their children.

Methods

Leptin and adiponectin concentrations at delivery and children's BMI z scores between age 4 weeks and 8 years were measured. Differences in BMI z scores and rates of BMI z score change by leptin (n?=?257) and adiponectin (n?=?271) terciles were estimated.

Results

Children in the middle (mean difference: 0.2; 95% CI: -0.1 to 0.4) and highest (0.4; 95% CI: 0.1 to 0.6) leptin terciles had greater BMI z scores than children in the lowest tercile. Associations were null after adjustment for birth weight z score. Children in the lowest adiponectin tercile had greater gains in BMI z score (change per year: 0.10; 95% CI: 0.08 to 0.13) than children in the middle (0.07; 95% CI: 0.04 to 0.09) and highest terciles (0.04; 95% CI: -0.01 to 0.05) (adiponectin × age interaction P?ConclusionsLower adiponectin levels were associated with increased rates of BMI gains in the first 8 years of life. Though leptin was positively associated with BMI, this association may be confounded by birth weight.

SUBMITTER: Buck CO

PROVIDER: S-EPMC6656611 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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Publications

Neonatal Adipocytokines and Longitudinal Patterns of Childhood Growth.

Buck Catherine O CO Eliot Melissa N MN Kelsey Karl T KT Chen Aimin A Kalkwarf Heidi H Lanphear Bruce P BP Braun Joseph M JM

Obesity (Silver Spring, Md.) 20190614 8

<h4>Objective</h4>Adipocytokines are markers of fetal metabolism, but their association with childhood growth is unclear. This study examined associations of neonatal adipocytokines with longitudinal childhood adiposity measures in a prospective cohort of pregnant women and their children.<h4>Methods</h4>Leptin and adiponectin concentrations at delivery and children's BMI z scores between age 4 weeks and 8 years were measured. Differences in BMI z scores and rates of BMI z score change by leptin ...[more]

PMID: 31199076

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Dataset Information

Neonatal Adipocytokines and Longitudinal Patterns of Childhood Growth.

Objective

Methods

Results

Publications

Neonatal Adipocytokines and Longitudinal Patterns of Childhood Growth.

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