Ontology highlight
ABSTRACT:
SUBMITTER: Imanikia S
PROVIDER: S-EPMC6656787 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Imanikia Soudabeh S Sheng Ming M Castro Cecilia C Griffin Julian L JL Taylor Rebecca C RC
Cell reports 20190701 3
The endoplasmic reticulum unfolded protein response (UPR<sup>ER</sup>) is a cellular stress response that maintains homeostasis within the secretory pathway, regulates glucose and lipid metabolism, and influences longevity. To ask whether this role in lifespan determination depends upon metabolic intermediaries, we metabotyped C. elegans expressing the active form of the UPR<sup>ER</sup> transcription factor XBP-1, XBP-1s, and found many metabolic changes. These included reduced levels of trigly ...[more]