Ontology highlight
ABSTRACT:
SUBMITTER: Littlejohn NK
PROVIDER: S-EPMC7575325 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Littlejohn Nicole K NK Seban Nicolas N Liu Chung-Chih CC Srinivasan Supriya S
eLife 20201020
The relationship between lipid metabolism and longevity remains unclear. Although fat oxidation is essential for weight loss, whether it remains beneficial when sustained for long periods, and the extent to which it may attenuate or augment lifespan remain important unanswered questions. Here, we develop an experimental handle in the <i>Caenorhabditis elegans</i> model system, in which we uncover the mechanisms that connect long-term fat oxidation with longevity. We find that sustained β-oxidati ...[more]