A comprehensive framework for physiologically based pharmacokinetic modelling in Matlab®.
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ABSTRACT:
SUBMITTER: Stader F
PROVIDER: S-EPMC6657005 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Publications
A Comprehensive Framework for Physiologically-Based Pharmacokinetic Modeling in Matlab.
Stader Felix F Penny Melissa A MA Siccardi Marco M Marzolini Catia C
CPT: pharmacometrics & systems pharmacology 20190402 7
Physiologically-based pharmacokinetic (PBPK) models are useful tools to predict clinical scenarios for special populations for whom there are high hurdles to conduct clinical trials such as children or the elderly. However, the coding of a PBPK model in a mathematical programming language can be challenging. This tutorial illustrates how to build a whole-body PBPK model in Matlab to answer specific pharmacological questions involving drug disposition and magnitudes of drug-drug interactions in d ...[more]
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