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ABSTRACT:
SUBMITTER: Mavroudis PD
PROVIDER: S-EPMC6709424 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Mavroudis Panteleimon D PD Ayyar Vivaswath S VS Jusko William J WJ
CPT: pharmacometrics & systems pharmacology 20190710 8
Minimal physiologically-based pharmacokinetic (mPBPK) models are frequently used to model plasma pharmacokinetic (PK) data and utilize and yield physiologically relevant parameters. Compared with classical compartment and whole-body physiologically-based pharmacokinetic modeling approaches, mPBPK models maintain a structure of intermediate physiological complexity that can be adequately informed by plasma PK data. In this tutorial, we present a MATLAB-based tool for the modeling and simulation o ...[more]