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Exact distance measurements for structure and dynamics in solid proteins by fast-magic-angle-spinning NMR.

ABSTRACT: Fast-magic-angle-spinning solid-state NMR is a developing technique for determination of protein structure and dynamics. Proton-proton correlations usually lead to rough distance restraints, a serious hurdle towards high-resolution structures. Analogous to the "eNOE" concept in solution, an integrative approach for more accurate restraints enables improved structural accuracy with minimal analytical effort.

SUBMITTER: Grohe K

PROVIDER: S-EPMC6658100 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Exact distance measurements for structure and dynamics in solid proteins by fast-magic-angle-spinning NMR.

Grohe Kristof K Nimerovsky Evgeny E Singh Himanshu H Vasa Suresh K SK Söldner Benedikt B Vögeli Beat B Rienstra Chad M CM Linser Rasmus R

Chemical communications (Cambridge, England) 20190614 55

Fast-magic-angle-spinning solid-state NMR is a developing technique for determination of protein structure and dynamics. Proton-proton correlations usually lead to rough distance restraints, a serious hurdle towards high-resolution structures. Analogous to the "eNOE" concept in solution, an integrative approach for more accurate restraints enables improved structural accuracy with minimal analytical effort. ...[more]

PMID: 31199417

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