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Cholestatic liver diseases: An era of emerging therapies.

ABSTRACT: Recently the field of cholestasis has expanded enormously reflecting an improved understanding of the molecular mechanisms underlying bile secretion and its perturbation in chronic cholestatic disease. Novel anti-cholestatic therapeutic options have been developed for patients not favorably responding to ursodeoxycholic acid (UDCA), the current standard treatment for cholestatic liver disease. Important novel treatment targets now also include nuclear receptors involved in bile acid (BA) homoeostasis like farnesoid X receptor and G protein-coupled receptors e.g., the G-protein-coupled BA receptor "transmembrane G coupled receptor 5". Fibroblast growth factor-19 and enterohepatic BA transporters also deserve attention as additional drug targets as does the potential treatment agent norUDCA. In this review, we discuss recent and future promising therapeutic agents and their potential molecular mechanisms in cholestatic liver disorders.

SUBMITTER: Samant H

PROVIDER: S-EPMC6658370 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Cholestatic liver diseases: An era of emerging therapies.

Samant Hrishikesh H Manatsathit Wuttiporn W Dies David D Shokouh-Amiri Hosein H Zibari Gazi G Boktor Moheb M Alexander Jonathan Steve JS

World journal of clinical cases 20190701 13

Recently the field of cholestasis has expanded enormously reflecting an improved understanding of the molecular mechanisms underlying bile secretion and its perturbation in chronic cholestatic disease. Novel anti-cholestatic therapeutic options have been developed for patients not favorably responding to ursodeoxycholic acid (UDCA), the current standard treatment for cholestatic liver disease. Important novel treatment targets now also include nuclear receptors involved in bile acid (BA) homoeos ...[more]

PMID: 31367616

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