Review: Pathogenesis of cholestatic liver diseases.
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ABSTRACT:
SUBMITTER: Yokoda RT
PROVIDER: S-EPMC7475774 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Publications
Review: Pathogenesis of cholestatic liver diseases.
Yokoda Raquel T RT Rodriguez Eduardo A EA
World journal of hepatology 20200801 8
Cholestatic liver diseases (CLD) begin to develop after an impairment of bile flow start to affect the biliary tree. Cholangiocytes actively participate in the liver response to injury and repair and the intensity of this reaction is a determinant factor for the development of CLD. Progressive cholangiopathies may ultimately lead to end-stage liver disease requiring at the end orthotopic liver transplantation. This narrative review will discuss cholangiocyte biology and pathogenesis mechanisms i ...[more]
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