Otopathogenic Staphylococcus aureus Invades Human Middle Ear Epithelial Cells Primarily through Cholesterol Dependent Pathway.
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ABSTRACT:
SUBMITTER: Mittal R
PROVIDER: S-EPMC6658548 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Publications
Otopathogenic Staphylococcus aureus Invades Human Middle Ear Epithelial Cells Primarily through Cholesterol Dependent Pathway.
Mittal Rahul R Debs Luca H LH Patel Amit P AP Nguyen Desiree D Blackwelder Patricia P Yan Denise D Weckwerth Paulo H PH Liu Xue Zhong XZ
Scientific reports 20190725 1
Chronic suppurative otitis media (CSOM) is one of the most common infectious diseases of the middle ear especially affecting children, leading to delay in language development and communication. Although Staphylococcus aureus is the most common pathogen associated with CSOM, its interaction with middle ear epithelial cells is not well known. In the present study, we observed that otopathogenic S. aureus has the ability to invade human middle ear epithelial cells (HMEECs) in a dose and time depen ...[more]
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