Dataset Information

Repeated Detection of Carbapenemase-Producing Escherichia coli in Gulls Inhabiting Alaska.

ABSTRACT: Here, we report the first detection of carbapenemase-producing Escherichia coli in Alaska and in wildlife in the United States. Wild bird (gull) feces sampled at three locations in Southcentral Alaska yielded isolates that harbored plasmid-encoded bla KPC-2 or chromosomally encoded bla OXA-48 and genes associated with antimicrobial resistance to up to eight antibiotic classes.

SUBMITTER: Ahlstrom CA

PROVIDER: S-EPMC6658779 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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Repeated Detection of Carbapenemase-Producing Escherichia coli in Gulls Inhabiting Alaska.

Ahlstrom Christina A CA Ramey Andrew M AM Woksepp Hanna H Bonnedahl Jonas J

Antimicrobial agents and chemotherapy 20190725 8

Here, we report the first detection of carbapenemase-producing Escherichia coli in Alaska and in wildlife in the United States. Wild bird (gull) feces sampled at three locations in Southcentral Alaska yielded isolates that harbored plasmid-encoded blaKPC-2 or chromosomally encoded blaOXA-48 and genes associated with antimicrobial resistance to up to eight antibiotic classes. ...[more]

PMID: 31209000

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Project description:BACKGROUND:The rapidly increasing dissemination of carbapenem-resistant Enterobacteriaceae (CRE) in both humans and animals poses a global threat to public health. However, the transmission of CRE between humans and animals has not yet been well studied. OBJECTIVES:We investigated the prevalence, risk factors, and drivers of CRE transmission between humans and their backyard animals in rural China. METHODS:We conducted a comprehensive sampling strategy in 12 villages in Shandong, China. Using the household [residents and their backyard animals (farm and companion animals)] as a single surveillance unit, we assessed the prevalence of CRE at the household level and examined the factors associated with CRE carriage through a detailed questionnaire. Genetic relationships among human- and animal-derived CRE were assessed using whole-genome sequencing-based molecular methods. RESULTS:A total of 88 New Delhi metallo-?-lactamases-type carbapenem-resistant Escherichia coli (NDM-EC), including 17 from humans, 44 from pigs, 12 from chickens, 1 from cattle, and 2 from dogs, were isolated from 65 of the 746 households examined. The remaining 12 NDM-EC were from flies in the immediate backyard environment. The NDM-EC colonization in households was significantly associated with a) the number of species of backyard animals raised/kept in the same household, and b) the use of human and/or animal feces as fertilizer. Discriminant analysis of principal components (DAPC) revealed that a large proportion of the core genomes of the NDM-EC belonged to strains from hosts other than their own, and several human isolates shared closely related core single-nucleotide polymorphisms and blaNDM genetic contexts with isolates from backyard animals. CONCLUSIONS:To our knowledge, we are the first to report evidence of direct transmission of NDM-EC between humans and animals. Given the rise of NDM-EC in community and hospital infections, combating NDM-EC transmission in backyard farm systems is needed. https://doi.org/10.1289/EHP5251.

Dataset Information

Repeated Detection of Carbapenemase-Producing Escherichia coli in Gulls Inhabiting Alaska.

Publications

Repeated Detection of Carbapenemase-Producing Escherichia coli in Gulls Inhabiting Alaska.

Similar Datasets

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