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T Cell Dysfunction in Cancer Immunity and Immunotherapy.

ABSTRACT: In cancer, T cells become dysfunctional owing to persistent antigen exposure. Dysfunctional T cells are characterized by reduced proliferative capacity, decreased effector function, and overexpression of multiple inhibitory receptors. Due to the presence of various inhibitory signals in the complex tumor microenvironment, tumor-specific T cells have distinct dysfunction states. Therapeutic reactivation of tumor-specific T cells has yielded good results in cancer patients. Here, we review the hallmarks of T cell dysfunction in cancer. Also, we discuss the relationship between T cell dysfunction and cancer immunotherapy.

SUBMITTER: Xia A

PROVIDER: S-EPMC6659036 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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T Cell Dysfunction in Cancer Immunity and Immunotherapy.

Xia Anliang A Zhang Yan Y Xu Jiang J Yin Tailang T Lu Xiao-Jie XJ

Frontiers in immunology 20190719

In cancer, T cells become dysfunctional owing to persistent antigen exposure. Dysfunctional T cells are characterized by reduced proliferative capacity, decreased effector function, and overexpression of multiple inhibitory receptors. Due to the presence of various inhibitory signals in the complex tumor microenvironment, tumor-specific T cells have distinct dysfunction states. Therapeutic reactivation of tumor-specific T cells has yielded good results in cancer patients. Here, we review the hal ...[more]

PMID: 31379886

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