Ontology highlight
ABSTRACT:
SUBMITTER: Hsu AY
PROVIDER: S-EPMC6659728 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Hsu Alan Y AY Liu Sheng S Syahirah Ramizah R Brasseale Kent A KA Wan Jun J Deng Qing Q
Molecular immunology 20190605
Neutrophil migration is essential for battling against infections but also drives chronic inflammation. Since primary neutrophils are terminally differentiated and not genetically tractable, leukemia cells such as HL-60 are differentiated into neutrophil-like cells to study mechanisms underlying neutrophil migration. However, constitutive overexpression or inhibition in this cell line does not allow the characterization of the genes that affect the differentiation process. Here we apply the tet- ...[more]