Ontology highlight
ABSTRACT:
SUBMITTER: Moldenhauer H
PROVIDER: S-EPMC6660193 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Moldenhauer Hans H Díaz-Franulic Ignacio I Poblete Horacio H Naranjo David D
eLife 20190704
In silico and in vitro studies have made progress in understanding protein-protein complex formation; however, the molecular mechanisms for their dissociation are unclear. Protein-protein complexes, lasting from microseconds to years, often involve induced-fit, challenging computational or kinetic analysis. Charybdotoxin (CTX), a peptide from the <i>Leiurus</i> scorpion venom, blocks voltage-gated K<sup>+</sup>-channels in a unique example of binding/unbinding simplicity. CTX plugs the external ...[more]