Data on autophagy markers in human macrophages exposed to oxLDL and growth differentiation factor-15.

ABSTRACT: Growth differentiation factor-15 (GDF-15) is a member of the TGF-? superfamily, identical to M?-inhibitory cytokine-1 (MIC-1). GDF-15 is associated with e.g. cardiovascular disease, inflammation and development of atherosclerosis and is highly expressed in macrophages (M?) of atherosclerotic lesions. Moreover, there exists an indication for the involvement of oxidized-low density lipoprotein (oxLDL) uptake and autophagic processes by M? regarding arteriosclerotic progression. Thus, we were interested to investigate a potential regulatory effect of GDF-15 on autophagy signaling pathway in human M? during foam cell formation. Here, we present western blot data of ATG5, ATG12/ATG5-complex and p62 regarding the GDF-15 concentration. For further interpretation of the data presented in this article, please see the research article "Growth differentiation factor-15 regulates oxLDL-induced lipid homeostasis and autophagy in human macrophages" [1].

SUBMITTER: Ackermann K 

PROVIDER: S-EPMC6660620 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature