Ontology highlight
ABSTRACT:
SUBMITTER: Blum T
PROVIDER: S-EPMC6660783 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Blum Thomas T Moreno-Pérez Ana A Pyrski Martina M Bufe Bernd B Arifovic Anela A Weissgerber Petra P Freichel Marc M Zufall Frank F Leinders-Zufall Trese T
Proceedings of the National Academy of Sciences of the United States of America 20190708 30
Dopamine neurons of the hypothalamic arcuate nucleus (ARC) tonically inhibit the release of the protein hormone prolactin from lactotropic cells in the anterior pituitary gland and thus play a central role in prolactin homeostasis of the body. Prolactin, in turn, orchestrates numerous important biological functions such as maternal behavior, reproduction, and sexual arousal. Here, we identify the canonical transient receptor potential channel Trpc5 as an essential requirement for normal function ...[more]