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Catalytic Alkyne Arylation Using Traceless Directing Groups.

ABSTRACT: By using Pd0 /Mandyphos, we achieved a three-component aminoarylation of alkynes to generate enamines, which are then hydrolyzed to either ?-arylphenones or ?,?-diarylketones. This Pd-catalyzed method overcomes established known pathways to enable the use of amines as traceless directing groups for C-C bond formation.

SUBMITTER: Park JW 

PROVIDER: S-EPMC6661160 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

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Catalytic Alkyne Arylation Using Traceless Directing Groups.

Park Jung-Woo JW   Kang Bubwoong B   Dong Vy M VM  

Angewandte Chemie (International ed. in English) 20180911 41

By using Pd<sup>0</sup> /Mandyphos, we achieved a three-component aminoarylation of alkynes to generate enamines, which are then hydrolyzed to either α-arylphenones or α,α-diarylketones. This Pd-catalyzed method overcomes established known pathways to enable the use of amines as traceless directing groups for C-C bond formation. ...[more]

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