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Synthesis of Novel Triazinoindole-Based Thiourea Hybrid: A Study on ?-Glucosidase Inhibitors and Their Molecular Docking.

ABSTRACT: A new class of triazinoindole-bearing thiosemicarbazides (1-25) was synthesized and evaluated for ?-glucosidase inhibitory potential. All synthesized analogs exhibited excellent inhibitory potential, with IC50 values ranging from 1.30 ± 0.01 to 35.80 ± 0.80 µM when compared to standard acarbose (an IC50 value of 38.60 ± 0.20 µM). Among the series, analogs 1 and 23 were found to be the most potent, with IC50 values of 1.30 ± 0.05 and 1.30 ± 0.01 µM, respectively. The structure-activity relationship (SAR) was mainly based upon bringing about different substituents on the phenyl rings. To confirm the binding interactions, a molecular docking study was performed.

SUBMITTER: Taha M

PROVIDER: S-EPMC6864627 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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Synthesis of Novel Triazinoindole-Based Thiourea Hybrid: A Study on α-Glucosidase Inhibitors and Their Molecular Docking.

Taha Muhammad M Alshamrani Foziah J FJ Rahim Fazal F Hayat Shawkat S Ullah Hayat H Zaman Khalid K Imran Syahrul S Khan Khalid Mohammed KM Naz Farzana F

Molecules (Basel, Switzerland) 20191023 21

A new class of triazinoindole-bearing thiosemicarbazides (1-25) was synthesized and evaluated for α-glucosidase inhibitory potential. All synthesized analogs exhibited excellent inhibitory potential, with IC50 values ranging from 1.30 ± 0.01 to 35.80 ± 0.80 µM when compared to standard acarbose (an IC50 value of 38.60 ± 0.20 µM). Among the series, analogs 1 and 23 were found to be the most potent, with IC50 values of 1.30 ± 0.05 and 1. ...[more]

PMID: 31652777

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