Occupational exposure and airflow obstruction and self-reported COPD among ever-employed US adults using a COPD-job exposure matrix.

ABSTRACT: INTRODUCTION:This study examined the association of spirometry-defined airflow obstruction and self-reported COPD defined as self-reported doctor diagnosed chronic bronchitis or emphysema, with occupational exposure among ever-employed US adults. METHODS:Data were obtained from the National Health and Nutrition Examination Survey (NHANES) 2007-2008 to 2011-2012, a nationally representative study of the non-institutionalized civilian US population. Reported current and/or longest held job were used to create prevalence estimates and prevalence odds ratios (PORs) (adjusted for age, gender, race, and smoking status) for airflow obstruction and self-reported COPD by occupational exposure, determined using both NHANES participants' self-reported exposures and eight categories of COPD job exposure matrix (JEM) assigned exposures. RESULTS:Significant PORs for airflow obstruction and self-reported COPD respectively were observed with self-reported exposure for ?20 years to mineral dust (POR?=?1.44; 95% confidence interval (CI) 1.13-1.85; POR?=?1.69; 95% CI 1.17-2.43) and exhaust fumes (POR?=?1.65; 95% CI 1.27-2.15; POR?=?2.22; 95% CI 1.37-3.58). Airflow obstruction or self-reported COPD were also associated with COPD-JEM assigned high exposure to mineral dust, combined dust, diesel exhaust, vapor-gas, sensitizers, and overall exposure. CONCLUSION:Airflow obstruction and self-reported COPD are associated with both self-reported and JEM-assigned exposures.

SUBMITTER: Doney B 

PROVIDER: S-EPMC6661888 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature