Genetic variation in the Hippo pathway and breast cancer risk in women of African ancestry.
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ABSTRACT:
SUBMITTER: Wang S
PROVIDER: S-EPMC6662580 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Publications
Genetic variation in the Hippo pathway and breast cancer risk in women of African ancestry.
Wang Shengfeng S Huo Dezheng D Ogundiran Temidayo O TO Ojengbede Oladosu O Zheng Wei W Nathanson Katherine L KL Nemesure Barbara B Ambs Stefan S Olopade Olufunmilayo I OI Zheng Yonglan Y
Molecular carcinogenesis 20180614 10
Gene expression changes within the Hippo pathway were found to be associated with large tumor size and metastasis in breast cancer. The combined effect of genetic variants in genes of this pathway may have a causal role in breast cancer development. We examined 7086 SNPs that were not highly correlated (r<sup>2</sup> < 0.8) in 35 Hippo pathway genes using data from the genome-wide association study of breast cancer from the Root Consortium, which includes 3686 participants of African ancestry f ...[more]
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