Ontology highlight
ABSTRACT:
SUBMITTER: Raqib R
PROVIDER: S-EPMC6663145 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Raqib Rubhana R Sarker Protim P Zaman K K Alam Nur Haque NH Wierzba Thomas F TF Maier Nicole N Talukder Kaisar K Baqui Abdullah Hel AH Suvarnapunya Akamol E AE Qadri Firdausi F Walker Richard I RI Fix Alan A Venkatesan Malabi M MM
Human vaccines & immunotherapeutics 20190319 6
<i>Shigella sonnei</i> live vaccine candidate, WRSS1, which was previously evaluated in US, Israeli and Thai volunteers, was administered orally to Bangladeshi adults and children to assess its safety, clinical tolerability and immunogenicity. In a randomized, placebo-controlled, dose-escalation, age-descending study, 39 adults (18-39 years) and 64 children (5-9 years) were enrolled. Each adult cohort (n = 13) received one dose of 3x10<sup>4</sup>, or three doses of 3 × 10<sup>5</sup> or 3 × 10< ...[more]