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Cigarette smoking and cerebral blood flow in a cohort of middle-aged adults.


ABSTRACT: Cigarette smoking is often associated with dementia. This association is thought to be mediated by hypoperfusion; however, how smoking behavior relates to cerebral blood flow (CBF) remains unclear. Using data from the Coronary Artery Risk Development in Young Adults (CARDIA) cohort (mean age?=?50; n?=?522), we examined the association between smoking behavior (status, cumulative pack-years, age at smoking initiation, and years since cessation) and CBF (arterial spin labeling) in brain lobes and regions linked to dementia. We used adjusted linear regression models and tested whether associations differed between current and former-smokers. Compared to never-smokers, former-smokers had lower CBF in the parietal and occipital lobes, cuneus, precuneus, putamen, and insula; in contrast, current-smokers did not have lower CBF. The relationship between pack-years and CBF was different between current and former-smokers (p for interaction?

SUBMITTER: Elbejjani M 

PROVIDER: S-EPMC6668508 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Cigarette smoking and cerebral blood flow in a cohort of middle-aged adults.

Elbejjani Martine M   Auer Reto R   Dolui Sudipto S   Jacobs David R DR   Haight Thaddeus T   Goff David C DC   Detre John A JA   Davatzikos Christos C   Bryan R Nick RN   Launer Lenore J LJ  

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20180122 7


Cigarette smoking is often associated with dementia. This association is thought to be mediated by hypoperfusion; however, how smoking behavior relates to cerebral blood flow (CBF) remains unclear. Using data from the Coronary Artery Risk Development in Young Adults (CARDIA) cohort (mean age = 50; <i>n</i> = 522), we examined the association between smoking behavior (status, cumulative pack-years, age at smoking initiation, and years since cessation) and CBF (arterial spin labeling) in brain lob  ...[more]

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