Ontology highlight
ABSTRACT:
SUBMITTER: Lotinun S
PROVIDER: S-EPMC6668688 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Lotinun Sutada S Ishihara Yoshihito Y Nagano Kenichi K Kiviranta Riku R Carpentier Vincent T VT Neff Lynn L Parkman Virginia V Ide Noriko N Hu Dorothy D Dann Pamela P Brooks Daniel D Bouxsein Mary L ML Wysolmerski John J Gori Francesca F Baron Roland R
The Journal of clinical investigation 20190521 8
Lactation induces bone loss to provide sufficient calcium in the milk, a process that involves osteoclastic bone resorption but also osteocytes and perilacunar resorption. The exact mechanisms by which osteocytes contribute to bone loss remain elusive. Osteocytes express genes required in osteoclasts for bone resorption, including cathepsin K (Ctsk), and lactation elevates their expression. We show that Ctsk deletion in osteocytes prevented the increase in osteocyte lacunar area seen during lact ...[more]