Ontology highlight
ABSTRACT:
SUBMITTER: Yang WT
PROVIDER: S-EPMC6668781 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Yang Wen-Ting WT Zhao Zong-Xia ZX Li Bin B Zheng Peng-Sheng PS
PloS one 20190731 7
Roles for SOX2 have been extensively studied in several types of cancer, including colorectal cancer, glioblastoma and breast cancer, with particular emphasis placed on the roles of SOX2 in cancer stem cell. Our previous study identified SOX2 as a marker in cervical cancer stem cells driven by a full promoter element of SOX2 EGFP reporter. Here, dual-luciferase reporter and mutagenesis analyses were employed, identifying key cis-elements in the SOX2 promoter, including binding sites for SOX2, OC ...[more]