Ontology highlight
ABSTRACT:
SUBMITTER: Dong J
PROVIDER: S-EPMC6669017 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Dong Jiantong J Jan Yu Jen YJ Cheng Ju J Zhang Ryan Y RY Meng Meng M Smalley Matthew M Chen Pin-Jung PJ Tang Xinghong X Tseng Patrick P Bao Lirong L Huang Tzu-Yang TY Zhou Dongjing D Liu Yupin Y Chai Xiaoshu X Zhang Haibo H Zhou Anqi A Agopian Vatche G VG Posadas Edwin M EM Shyue Jing-Jong JJ Jonas Steven J SJ Weiss Paul S PS Li Mengyuan M Zheng Guangjuan G Yu Hsiao-Hua HH Zhao Meiping M Tseng Hsian-Rong HR Zhu Yazhen Y
Science advances 20190731 7
Well-preserved mRNA in circulating tumor cells (CTCs) offers an ideal material for conducting molecular profiling of tumors, thereby providing a noninvasive diagnostic solution for guiding treatment intervention and monitoring disease progression. However, it is technically challenging to purify CTCs while retaining high-quality mRNA.Here, we demonstrate a covalent chemistry-based nanostructured silicon substrate ("Click Chip") for CTC purification that leverages bioorthogonal ligation-mediated ...[more]